Chronic Intermittent Cold Exposure on Weight Loss

Inclusion Criteria: * BMI \> 30 (inclusive) * Body weight less than 120 kg * Weight stability for 3 months * Plasma triglyceride concentration less than 3.0 mmol/l * Plasma HDL-cholesterol more than 0.9 mmol/l in males and more than 1.0 mmol/l in females * Blood pressure less than 140/90 mmHg (inclusive) * Normal glucose tolerance or impaired glucose tolerance but not diabetes (fasting glucose \< 7.0 mmol/l or 2 h glucose in the oral glucose tolerance test \< 11.1 mmol/l) Exclusion Criteria: * Smoking * Frequent weight loss attempts * Pregnancy or lactation * Diabetes mellitus * Hypo/hyperthyreosis * Cardiovascular disease, stroke or neurological disorder * Medication (antihypertensive and antidiabetic drugs, lipid lowering drugs, antidepressants, corticosteroids) * Claustrophobia * Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results. * Presence of any ferromagnetic objects that would make MRI imaging contraindicated