Safety and Intraocular Pressure (IOP) Lowering Effect of AL-59412C

Inclusion Criteria: * Diagnosis of primary open-angle glaucoma or ocular hypertension. * Retinal pathology (eg, retinal degeneration), anterior ischemic optic neuropathy, or vascular occlusion resulting in poor vision in the study eye. * Able to discontinue all intraocular-lowering (IOP) medications according to the minimum washout period, based upon the class of medication. * Mean washed out IOP ≥ 24 millimeters mercury (mmHg) to ≤ 36 mmHg at 8 AM in the study eye on two separate Eligibility Visits. * Other protocol-defined inclusion criteria may apply. Exclusion Criteria: * Lens/corneal/vitreal opacity preventing adequate posterior segment visualization of the study eye. * Current or recent (within 30 days) use of any drug that may prolong the QT interval. * Poor vision resulting from advanced glaucoma in the study eye. * Intraocular surgery within the past 6 months in the study eye. * Ocular laser surgery within the past 3 months in the study eye. * Other protocol-defined exclusion criteria may apply.