This study is investigating the effect of 8 weeks of orange juice supplementation on executive function in healthy older adults. The study is a controled, double-blind, crossover trial and involves a 8 week supplementation with a high flavonone orange juice and a carbohydrate-matched control. Volunteers consume 500ml of either the test juice or the control juice per day for an 8 week period. There is then an 8 week washout period before subjects proceed to the other arm of the study. Subjects are randomly assigned to either arm at the beginning of the study. Measures of cognitive function will be administered pre and post both test and control interventions. Blood pressure will also be measured and blood and urine samples will be collected to assess absorption of from the juice. A sub-sample of volunteers will undergo MRI imaging pre- and post intervention to acquire cerebral blow flow information.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
40
High flavonone orange juice drink.
Orange beverage, low flavanone content, matched for total carbohydrate content, individual sugar profile, vitamin C
University of Reading
Reading, Berkshire, United Kingdom
Executive function - Attention
Assessment by human cognitive test battery delivered by computer and human operator. Assessments will be carried out at baseline and at the end of each intervention arm.
Time frame: change in attention from baseline and 8 weeks
Plasma flavanones
By High performance liquid chromatography
Time frame: change from baseline to 8 weeks
Blood pressure
Blood pressure measurement
Time frame: change from baseline to 8 weeks
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