A Short Term Pharmacokinetic, Pharmacodynamic and Tolerability Study to Compare AOP200704 vs. Esmolol

Inclusion Criteria: * Male and female human subjects, age 18-45 years * Body weight of at least 50 kg, maximum of 90 kg. Body-mass index 18.5 to 30.0 kg/m2 * Caucasians * Subjects without clinically relevant abnormalities * Subjects agreeing to not using any prescription and over the counter medications including vitamins and minerals for 7 days prior to study and during the course of the study * No drug or alcohol abuse * Non-smokers, ex smokers and mild smokers Exclusion Criteria: * Subjects with history or presence of clinically relevant cardiovascular, renal, hepatic, ophthalmic, pulmonary, neurological, metabolic, hematological, gastrointestinal, endocrine, immunological, psychiatric or skin diseases. * Subjects with bradycardia (heart rate below 50 bpm), tachycardia (heart rate above 100 bpm), hypotension (systolic blood pressure below 100 mmHg, and/or diastolic blood pressure below 70 mm Hg) at screening, clinically relevant or history of clinically relevant arrhythmias * Subjects with clinically relevant cardiac supraventricular or ventricular arrhythmias. * Subjects with atrioventricular block of grade II and III, sick sinus syndrome, sinoatrial block or congestive heart failure * Participation in a clinical drug study or bioequivalence study 60 days prior to present study. * History of malignancy or other serious diseases. * Any contraindication to blood sampling. * History of i.v. drug abuse. * Subjects with positive HIV tests, HBsAg or Hepatitis C tests or other acute, subacute or chronic infectious disease.