RPS InflammaDry Detector™ to Determine MMP-9 Levels in Tears

INCLUSION CRITERIA Patients older than 18 years of age, who meet the following criteria related to the clinical history and signs will be enrolled: Group 1: Clinical Dry Eyes Clinical History Criteria An Ocular Surface Disease Index (OSDI) of greater than or equal to 13 - \[Appendix #2\] Clinical Signs Criteria - All of the following must be present 1. Schirmer's Tear Test (with anesthesia) \< 10 mm over 5 minutes 2. Tear Film Break Up Time (TBUT) \< 10 seconds 3. Total Corneal Staining ≥ 1 \[Appendix #1\] * At least 1/2 of all patients enrolled will have a Schirmer's Tear Test \< 5 mm or demonstrate corneal staining ≥ 2 \[Appendix #1\] Group 2: Clinical Normal Non-Dry Eyes Clinical History Criteria An Ocular Surface Disease Index (OSDI) of \< 7 - \[Appendix #2\] Clinical Signs Criteria - All 3 of the following must be present 1. Schirmer's Tear Test (with anesthesia) ≥ 10 mm over 5 minutes 2. Tear Film Break Up Time (TBUT) ≥ 10 seconds 3. Total Corneal Staining = 0 \[Appendix #1\] EXCLUSION CRITERIA * Patients with allergy to corn starch, talcum powder, or dacron * Patients with prior eye injury, trauma, or ocular surgery within the previous 3 months * Patients with non-dry eye ocular inflammation, uveitis, history of herpetic keratitis or zoster keratitis * Patients with history of a recent ocular infection within the prior 1 month * Use of oral doxycycline or topical macrolides (AzaSite) within 1 month * Patients currently receiving, or received in the last 2 weeks of the study , certain medications including topical or systemic corticosteroids, topical or systemic Nonsteroidal (NSAIDs) therapy, topical cyclosporine, or other immunosuppressive therapy * Patients who are pregnant or lactating * Before initialization of the study, patients must not have used any topical medications, including artificial tears during the previous 2 hours * The use of Rigid-Gas permeable contact lenses or the use of soft-contact lenses within 1 month of the study