The Effect of IV Amantadine on Freezing of Gait (FOG) Resistant to Dopaminergic Therapy

Overview

Tp determine the effect of IV amantadine on dopaminergic-drug-resistant freezing of gait(FOG)in patients with Parkinson's disease

1. Freezing of gait (FOG) is one of the most disabling symptoms of Parkinson's disease. We experienced that severe FOG was markedly improved by IV amantadine in the patients who had Parkinson's disease. But IV drug may have placebo effect. Therefore, We designed double blind, placebo controlled study to know whether IV amantadine is effective in the patient with dopaminergic-drug-resistant freezing of gait(FOG). 2. Cross over study design * Compare the change of FOGQ(freezing of gait questionaire) score from the baseline to IV amantadine and placebo drug * randomized assigned order of amantadine and placebo drug. * investigator of FOG: blinded to the order of drugs * each patient has IV drug for 2 days for each drug

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Central Contacts