Efficacy Study on the Lipid-lowering Effect of Plant Sterols and Fish Oil

Inclusion Criteria: * Apparently healthy men and women * Age ≥ 25 and ≤ 75 years old * Body mass index (BMI) ≥ 18 and ≤ 30 kg/m2 * Total cholesterol levels at screening ≥ 5.0 and ≤ 8.0 mmol/L * 10-year CVD risk equal or lower than 10% according to "SCORE" * Blood pressure, heart rate, hematological parameters, clinical chemical parameters within normal reference ranges * Informed consent and biobank consent signed * Willing to comply to study protocol during study * Agreeing to be informed about medically relevant personal test-results by a physician * Not smoking * Accessible veins on the forearm * Habitually consuming spreads Exclusion Criteria: * Pregnant or having the wish to become pregnant, or lactating * Use of prescribed medication which may interfere with study measurements * Use of antibiotics in the 3 months before screening or during the study * Use of any medically- or self-prescribed diet with the purpose to reduce weight * Intolerance for gluten or lactose * Reported food allergy * Having bleeding disorders * Recent blood donation * Excessive alcohol consumption * Strenuous exercise * Reported weight change ≥ 10 % of body weight or use of prescribed weight reduction drugs * Recent participation in another nutritional or medical trial * Participation in night shift work