Influence of Clonidine on Thrombozytes of Blood of Patients Under Anticoagulation Therapy With ASS and Clopidogrel

Goethe University

Overview

Clonidin works as a presynaptic agonist of alpha-sympathomimetic receptors of the brain but also in many other tissues. It is part of balanced anesthesia in general anesthesiology as well as a sedastive agent in intensive care units, but also serves as a third-line agent in many psychiatric diseases including ADHD, schizophrenia and PTSD. The investigators want to show whether clonidin has an procoagulatoric effect on thrombozytes of patients under double anticoagulaotirc treatment with ASS and clopidogrel. The investigators will use a flowcytometric assay to determine activation of thrombozytes when they come into contact with clonidine in vitro as well as Multiplate analyses to determine activation of thrombozytes, either thrombin.induced aggregation, ADP-induced aggregation or arachidonic acid-induced aggregation of thrombozytes.

Study Type

OBSERVATIONAL

Conditions

Anticoagulation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elective vascular surgical patients with long-term medication (at least 5 days) with ASS and clopidogrel * Age above 18 years Exclusion Criteria: * Additional anticoagulatoric treatment woth another inhibitor of platelet aggregation * Surgery within the last two weeks * Patients with long-term mediaction with omeprazole * Patients under hemodialysis * Patients with renal insufficiency (creatinine above 1.5mg/dl, urea above 80mg/dl) * Patients with hepatic dysfunction (GOT above 30U/I, GPT above 30 U/I, GLDH above 10 U/I) * Age under 18 yeary * Non-responder to ASS and / or clopidogrel

Locations (1)

Johann-Wolfgang-Goethe University

Frankfurt am Main, Hesse, Germany

RECRUITING

Outcomes

Primary Outcomes

Numbers of participants with an activated area under the curve in ASPI test

Blood of patients under ASS and clopidogrel will show an activated platelet aggregation due to titrated clonidine in ASPI test, i.e. an activated area under the curve in Multiplate analysis.

Time frame: 30 minutes

Secondary Outcomes

Numbers of participants with an activated area under the curve in TRAP test and ADP test

Blood of patients under ASS and clopidogrel will show an activated platelet aggregation due to titrated clonidine in TRAP test and ADP test, i.e. an activated area under the curve in Multiplate analysis.

Time frame: 30 minutes

Data from ClinicalTrials.gov

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