A Methadone Maintenance Treatment Outcome Study in Three Provinces in China

Centers for Disease Control and Prevention4,258 enrolled

Overview

The primary goal of this PHE is to determine the effectiveness of a tailored education program for MMT service providers. It was to be evaluated through methadone dose levels prescribed to new patients after training completion. The effects of methadone dose, with and without the inclusion of additional counseling services, would be measured through MMT retention and illicit opioid use.

Methadone treatment has became one of main actions taken in China to control the spread of HIV among drug users. However，the average methadone dose used is relatively low. An intensive methadone maintenance treatment (MMT) provider training on methadone dosage may be effective in increasing the methadone dose levels prescribed to new patients. The study will evaluate the effectiveness of a tailored education program for MMT service providers using subsequent methadone dose prescribed to new patients. The effects of methadone dose, with and without the inclusion of additional psychosocial services, will then be measured through MMT retention and illicit opioid use.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

4,258

Conditions

HIV Hepatitis C Syphilis Herpes Simplex Type II

Interventions

MMT provider dosage trainingBEHAVIORAL

Training on methadone dosing provided to health care providers working in methadone maintenance clinics

targeted counselingBEHAVIORAL

targeted counseling provided to methadone maintenance clinic attendees

national guidelinesOTHER

Provided a hard copy of the existing national guidelines for methadone dosing

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * client participants will include both men and women who are opiate-dependent drug users who started MMT not more than one month prior to enrollment in the study * 18 years of age or older * residing in the study areas

Locations (1)

National Center for HIV/STD Prevention and Control, China CDC

Beijing, China

Outcomes

Primary Outcomes

MMT retention rate

% of patients retained at the end of the year after Methadone maintenance treatment

Time frame: 12 months

Illicit opioid use rate

by urinalysis and self-report

Time frame: 12 months

Secondary Outcomes

HIV, HCV, syphilis and HSV-2 infection seroconversion rate

Patients who were negative converted to being seropositive

Time frame: 12 months

High risk needle practice

Shared needles used for drug injections without cleaning procedures involved

Time frame: 12 months

High risk sexual practice

Sex without condoms and also with multiple partners

Time frame: 12 months

Quality of life（WHO Quality of Life -BREF）

Scale of quality of life by WHO

Time frame: 12 months

All-cause mortality

Patients die by all causes during the program

Time frame: 12 months

Data from ClinicalTrials.gov

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