Role of Heparin in Poor Responders Undergoing In Vitro Fertilisation

National and Kapodistrian University of Athens50 enrolled

Overview

The addition of heparin increases pregnancy outcome parameters in poor responders undergoing In Vitro Fertilisation (IVF)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Infertility

Interventions

Heparin, Low-Molecular-WeightDRUG

Heparin from start till hcg test

no heparinDRUG

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 43 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * poor responders (age\>40, abnormal ovarian test, \</=4 oocytes in previous cycle with conventional stimulation) * infertility, indication for IVF * no contraindications for heparin

Locations (1)

3rd Department of Obstetrics & Gynecology

Athens, Chaidari, Greece

Outcomes

Primary Outcomes

no of oocytes retrieved

\>2 between groups

Time frame: egg recovery, 2 years

Secondary Outcomes

clinical pregnancy rate

Presence of fetal heart at transvaginal ultrasound at 6+2 gestational weeks

Time frame: 2 years

live birth rate

\>20 weeks of gestation

Time frame: 2 years

cancellation rate

Time frame: before ET, 2 years

miscarriage rate

pregnancy loss \<20 weeks

Time frame: 2 years

Data from ClinicalTrials.gov

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