The pilot studies have showed that theta burst stimulation (TBS) can have the more rapid and durable effects to the apply traditional rTMS protocols. The aim of this study is to investigate the effect of repetitive TMS and theta burst in reduction of negative symptoms and remission of cognitive functioning in patients with schizophrenia. In a randomized, double blind clinical trials, 30 patients with schizophrenia in Razi psychiatric hospital will be assigned to receive repetitive TMS; theta burst, or sham TMS, daily; for 20 sessions. The negative symptoms and cognitive functioning will be assessed before the treatment (pre test) during the treatment (session 10), and after the treatment (post test).QEEG and LORETA apply before and after rTMS in all subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
30
* 3 pulses at 50Hz repeated each 200 ms for 2 seconds * 80% MT * 20 days treatment
LDLPFC 110% MT 15 Hz 20 days
Placebo treatment: Sham coil
Atieh Clinical Neuroscience Center (ACNC)
Tehran, Tehran Province, Iran
RECRUITINGPositive and negative syndrome scale ( PANSS )
Time frame: Change of baseline in negative symptoms at 20 sessions
Calgary depression for schizophrenia scale (CDSS)
The CDSS is administered for measuring of depression before treatment, session 10, immediately after treatment
Time frame: 3 times (Before treatment, session 10, immediately after treatment)
Schizophrenia quality of life scale (SQLS)
The SQLS is administered for apprising of quality of life before treatment, session 10, immediately after treatment.
Time frame: 3 times (Before treatment, session 10, immediately after treatment)
Cantab Schizophrenia Battery
Cantab Schizophrenia Battery is included six tests, which is measuring for cognitive function. The cognitive function includes reaction time, executive function, Sustained attention, , Episodic memory . These scales: Reaction time (RTI) Rapid Visual information processing (RVP) Spatial Working Memory (SWM) One Touch Stockings of Cambridge (OTS) Paired Associates Learning (PAL) Intra-Extra Dimensional set- Shift (IED)
Time frame: 3 times (Before treatment, session 10, immediately after treatment)
QEEG and low resolution brain electromagnetic tomography (LORETA)
QEEG and LORETA is applying for assessment brain waves patterns.
Time frame: 3 times (Before treatment,session 10, immediately after treatment)
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