Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation

Inclusion Criteria: * Healthy volunteers and patients with cystic fibrosis ≥ 18 \< 50 years of age * Healthy volunteers must be in general good health as determined by a medical history * CF subjects must have a documented diagnosis of CF (positive sweat chloride ≥ 60 mEq/liter, by pilocarpine iontophoresis) and/or a genotype with two identifiable mutations consistent with CF accompanied by one or more clinical features with the CF) phenotype * CF subjects must have a baseline FEV1 percent predicted \> 50% (in the last year, obtained from medical record) * CF subjects must be clinically stable: free of any acute illness for \> 14 days CF subjects must not have been prescribed any new systemic antibiotics for the 14 days prior to enrollment * Ability to provide written informed consent * Ability to adhere to the protocol Exclusion Criteria: * Use of NSAIDS (e.g., ibuprofen) or corticosteroids including inhaled steroids for the 4 weeks prior to enrollment * Active gingival disease (active tooth or gum disease) * History of nephrolithiasis or cholelithiasis * Allergy to broccoli * Any chronic condition that compromises the participant as determined by medical history * Pregnancy * Inability to tolerate the study procedures * CF subjects: Infected with B. cepacia