Alzheimer's Disease and Related Disorders

University Hospital, Angers700 enrolled

Overview

The purpose of this study is to compare characteristics of gait and balance measured among patients with Alzheimer's disease or related disorders separated into 3 groups according to the stage of disease (i.e., pre-dementia, mild and moderate dementia stages); to determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities; and to establish a database at Angers University Memory Centre.

Although gait disorders are frequently associated with Alzheimer's disease and related disorders (ADRD), few studies have focused on cognitive motor effects of anti-dementia drugs and vitamin D. The objectives of this study are to * Compare characteristics of gait and balance measured among patients with ADRD separated into 3 groups according to stages of disease (i.e., pre-dementia, mild and moderate dementia stages) * To determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities * To determine whether motor abnormalities could be associated with cognitive impairments, specifically executive dysfunctions * To establish a database at Angers University Memory Center.

Study Type

OBSERVATIONAL

Enrollment

700

Conditions

Alzheimer's Disease Gait Apraxia Impaired Cognition

Interventions

Drug interventionDRUG

before-after interventional (anti-dementia drugs and/or vitamin D) study

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * All elderly patients from the University Memory Center of Angers University Hospital. * Able to walk without any walking aid on 15 meters * Mini-Mental Status Examination score \> 10 * Being affiliated to a social security regime Exclusion Criteria: * Mini-Mental Status Examination score ≤ 10 * Subject suffering from pre-existing impellent disturbances * History of cerebrovascular accident or other cerebro-spinal pathology * Poor workmanship of the written or oral French language * Use of walking aid such as walking frame with wheels or tricycle. * Acute medical or surgical disease in the past 3 months * Refusal to participate (or trustworthy person) * Near visual acuity \< 2/10

Locations (1)

Cédric ANNWEILER , MD

Angers, France

RECRUITING

Outcomes

Primary Outcomes

Spatiotemporal gait parameters

Time frame: baseline

Central Contacts

Cedric ANNWEILER, DM

CONTACT

(+33) 241354725 ceannweiler@chu-angers.fr

Data from ClinicalTrials.gov

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