Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

N/ANot Yet RecruitingNCT01315782

The University of Texas Health Science Center, Houston30 enrolled

Overview

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation. Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sepsis Severe Sepsis Septic Shock Multi-organ Failure

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults with severe sepsis or septic shock on mechanical ventilation * Enrolled in the initial six hours of ICU admission Exclusion Criteria: * Patients with withdrawal or hospice order. * Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission. * Patients with COPD. * Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Outcomes

Primary Outcomes

Multi-organ failure

Multi-oran failure will be accessed by daily laboratory data, heart function by echocardiogram if available, urinary output, vitals and use of vasopressors.

Time frame: daily for 48 hours then weekly for 2 weeks.

Secondary Outcomes

Mortality

All the patient will be followed up to 28-days to determine survival.

Time frame: ICU mortality