Rate of Change of HbA1c (dx/dt) May Predict Progression to Type 2 DM

Wyckoff Heights Medical Center542 enrolled

Overview

The investigators hypothesize that the HbA1c shows a rising trend in pre-diabetics and normal population with risk factors of developing type 2 DM. There is no known diabetes model for predicting incident diabetes in an individual which takes into account the rate of change of HbA1c (dx/dt). In such cases, the rate of change of HbA1c may give the physicians lead time needed to implement the Diabetes Prevention Program measures.

Study Type

OBSERVATIONAL

Enrollment

542

Conditions

Diabetes Mellitus Type 2

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * No self-reported history of diabetes or pre-diabetes defined as per ADA criteria * Age greater than 18 years * Scheduled to receive HbA1c in participating clinic * Able and willing to give legally effective consent * Able and willing to participate in patient questionnaires(attached) Exclusion Criteria: * Previously or currently taking medications for lowering glucose (i.e., exenatide, pramlintide, metformin, rosiglitazone, pioglitazone, or future diabetes drugs) based on self-report and/or prescreening. Patients on drugs causing hyperglycemia like Oral Steroids will be excluded. * Baseline HbA1c level above 5.7 * Severe Anemia (defined as Hb less than 8gm/dL) * Patients with hemoglobinopathies * Pregnancy * Polycystic ovarian disease

Locations (1)

Wyckoff Heights Medical Center

Brooklyn, New York, United States

Outcomes

Primary Outcomes

Study the rate of change of HbA1c in normal population with known risk factors of diabetes

Time frame: one year

Secondary Outcomes

Diabetes prediction model based on the rate of change in HbA1c

To develop a mathematical model which will predict the onset of type 2 dm based on the rate of change in HbA1c valued leading to development of pre-diabetes

Time frame: one year

Data from ClinicalTrials.gov

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