A Randomized, Open, Prospective Clinical Research of Fluorouracil Implant to Improve Surgical Gallbladder Cancer and Bile Duct Cancer

Inclusion Criteria: * The patients with gallbladder and bile duct cancer diagnosis by surgical exploration, or intraoperative frozen biopsy (Annex 2). * Aged 18 to 70 years old, male or female, body condition score generally ECOG 0～2, expected survival ≥ 3 months. * Subjects were no major organ dysfunction, blood, liver, kidney and heart function was normal, the specific requirements of laboratory indicators: Blood: WBC count \> 3.0 × 109 / L, Platelet count\> 100 × 109 / L, Hb \> 8.0g/dl. Liver function：serum bilirubin less than 1.5 times the upper limit of normal; ALT and AST less than 3 times the upper limit of normal. Renal function: creatinine less than 1.5 times the upper limit of normal. * Participants have used other chemotherapy drugs, subject to the 30-day washout period before proceeding with the test. * Patients had no anaphylactic reaction with oxaliplatin and fluorouracil in the past. * Patients who can understand the circumstances of this study and signed informed consent. Exclusion Criteria: * Currently is receiving effective treatment； * Pregnancy, breast-feeding patients； * Primary brain tumors or central nervous system metastatic tumor is not controlled; * Patients received chemotherapy, radiotherapy, biological therapy, other drugs or instrument therapy 30 days before enrollment. * Patients with purulent and chronic infected wounds which delayed healing. * Patients with liver, kidney and heart failure and coronary heart disease, angina, myocardial infarction, arrhythmia, cerebral thrombosis, stroke and other serious cardiovascular and cerebrovascular disease; * Patients has a history of mental illness and difficult to control; * Patients who was considered inappropriate to participate in the trials by the researchers.