Protein Supply in Elderly

Maastricht University Medical Center16 enrolled

Overview

Stimulating overnight muscle protein synthesis, might augment muscle hypertrophy, increase mitochondrial mass, and/or improve muscle tissue repair. The goal of this proposal will be to provide further insight into the responsiveness of the muscle protein synthetic machinery to food intake in relation to age.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Muscle Synthesis

Interventions

ProteinDIETARY_SUPPLEMENT

Protein drink

Eligibility

Sex: MALEMin age: 65 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Males * Age between 65 and 80 years * BMI \< 30 kg/m2 Exclusion Criteria: * Type 2 diabetic patients * Use of medication * All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. artrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis). * Use of anticoagulants, blood diseases, allergy for lidocain. * Contra indications for the use of a nasogastric tube: high risk of aspiration, gastric stasis, gastro-oesophageal reflux, upper gastrointestinal stricture, nasal injuries and base of skull fractures. * Patients suffering from PKU (Phenylketonuria).

Locations (1)

Maastricht University Medical Centre

Maastricht, Limburg, Netherlands

Outcomes

Primary Outcomes

Protein synthesis

Overnight protein synthesis

Time frame: overnight (12 h)

Data from ClinicalTrials.gov

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