Nutrition and Body Composition in Acute Lymphoblastic Leukemia

Inclusion Criteria: GROUP A: Patients with newly diagnosed ALL * Are greater than or equal to 10 years of age and less than or equal to 21 years of age at diagnosis of ALL * Have a new diagnosis of untreated ALL classified as "high risk" per NCI criteria (due to being greater than 10 years of age) * Are beginning treatment with a Children's Cancer Group/Children's Oncology Group "high risk" protocol with a 4-drug induction including steroids * Are not pregnant GROUP B: Early survivors of ALL * Were treated for ALL and remain in first CR1 (complete remission) * Were equal to or greater than 10 years of age and less than or equal to 21 years of age at diagnosis of ALL * Have completed treatment on or as per a Children's Cancer Group/Children's Oncology Group "high risk" protocol between 12 and 48 months prior to enrollment in this study (consisting of a plan for a 4-drug induction including steroids in Induction, Delayed Intensification, and steroid pulses in Maintenance. Steroids are allowed to have been discontinued due to toxicity). * Are not pregnant GROUP C: Siblings of Group A * Are either a full-sibling or a half-sibling of a patient in Group A * Are living at the same residence as the sibling/half-sibling from Group A * Are greater than or equal to 10 years of age and less than or equal to 21 years of age at the time of study entry, and within 3 years of the age diagnosis of ALL in the sibling/half-sibling from Group A * Are on the same Vitamin D supplementation regimen (if any) as the sibling from Group A at the time of his or her diagnosis Exclusion Criteria (All Groups): * Have a diagnosis of Down syndrome (Trisomy 21) or any genetic disease associated with abnormal bone development * Are undergoing treatment with other medicines that affect bones including chronic use of of steroids, bisphosphonate therapy, or Vitamin D at average dose greater than 400 international units (IU)/day * Have an underlying diseases altering body structure (i.e. missing a limb, severe dysmorphism) or severely affecting mobility (i.e. total or hemiparesis) * Have a history of chemotherapy or radiation for other cancers * Cannot complete the radiology exams/radiology exams uninterpretable (i.e. people with a hip replacement or prosthesis)