AL-54478 Proof of Concept Study

Inclusion Criteria: * Patients diagnosed with either OAG or OHT. * Patients who are able to comply with the scheduled visits. * Patients who have had a physical exam within 6 months of the Screening Visit. * Other protocol-defined inclusion criteria may apply. Exclusion Criteria: * Females of childbearing potential who meet any 1 of the following conditions: a) Currently pregnant; b) Positive urine pregnancy test; c)Intend to become pregnant; d) Breast feeding; e) Not using highly effective birth control measures. * Patients with extreme narrow angle with complete or partial closure. * Patients with a cup to disc ratio more than 0.8. * Patients with a severe central visual field loss in either eye. * Patients with chronic or recurrent inflammatory eye disease or acute ocular infection or inflammation. * Patients who have had ocular trauma within the past 6 months or have had intraocular surgery within the past 6 months or have had ocular laser surgery within the past 3 months. * Patients with best-correct visual acuity less than 20/80. * Patients who have had ocular infection or inflammation within the past 3 months. * Patients who have clinically relevant progressive retinal disease. * Patients who have severe illness or conditions. * Patients who have hypersensitivity to a prostaglandin analogu.e * Patients who are unable to safely discontinue all IOP-lowering medications during washout. * Patients who are currently on therapy with another investigational agent within 30 days prior to the Screening Visit. * Other protocol-defined exclusion criteria may apply.