HepZero:Heparin Free Dialysis With Evodial

Inclusion Criteria: * Patients requiring heparin free dialysis treatments on nephrologists' prescription, * Chronic ESRD patients treated by maintenance hemodialysis for at least 3 months, * Patients with a well functioning blood access that can allow a blood flow of at least 250 ml/min, * Patients aged 18 years or more, * Written consent to participate in the study (informed consent). Exclusion Criteria: * Patients in ICU settings, * AKI patients, * Patients dialyzed in self care, satellite HD units, * Patients treated in single needle mode, * Known heparin contraindication (HIT type II), * Patients requiring blood and other labile blood products (i.e. fresh frozen plasma, platelets, etc …) transfusion during hemodialysis treatment, * Patients receiving oral anticoagulants (including Anti vitamin K), * Patients receiving a combination of anti-platelets agents, * Patients treated with unfractionated or low molecular weight heparin beside the dialysis treatment to prevent deep vein thrombosis, * Pregnant/ planning pregnancy and lactating women during study period, * Adult patients protected by the law, * Patients are not affiliated to health insurance system (beneficiary or dependant) * Participation in other interventional studies during the study period, * Patients that have already been included in this study.