Comparison of renal blood flow measurements by PAH clearance and MRI
The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
10
Renal blood flow is measured after the administration of 20 mg of furosemide during MRI scan only.
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Measurement of Renal Blood Flow of the Kidney by the PAH Method
Renal blood flow is estimated by the PAH method.
Time frame: Renal blood flow is estimated over 1 hour by PAH
Measurement of Regional Blood Oxygenation by MRI
Estimate of renal blood flow by using MRI scans before and after the administration of furosemide
Time frame: One measure after furosemide (day 1)
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