Reducing Drug Craving Memories

Inclusion Criteria: * 60 psychotropic medication-free men or women (15 subjects x 4 groups) who have met DSM-IV-TR diagnostic criteria for cocaine dependence for the past 6 months (age 18 - 50 years old); * Minimum of three days cocaine abstinent on study days; * Primary use of cocaine is intra-nasal or smoked crack Exclusion Criteria: * Medical conditions that might be aggravated by participation in the study: * cardiovascular disorders that might be aggravated by participation in the study: hypotension (SBP: \< 100 mmHg), bradycardia (heart rate \< 60 /min), severe atrioventricular block (Type II or III), severe hypertension (SBP: \> 160 mmHg; DBP: \> 100 mmHg), myocardial infarction, history of chest pain and admission to ED for chest pain; * respiratory disorders: bronchial asthma and chronic obstructive pulmonary disease; * diabetic patients treated with insulin or oral hypoglycemic agents. Propranolol may mask the first signs of a developing hypoglycemia. * Seropositive pregnancy test * Comorbidity with current axis I psychiatric disorders other than anxiety, affective and substance use disorders * Severe liver disfunction * Current or recent (\< 5 half lives) use of medications that may interact with Inderal (see above) * Positive urine tox screen for barbiturates. Positive breath alcohol screen. {Note: all urine tox screen results will be destroyed immediately after collection. The information will not be stored}