The purpose of this study is to compare different estimates of calculating creatinine clearance by mathematical formula and compare them to creatinine clearance based on a timed urine collection in patients who received high-dose methotrexate for the treatment of primary CNS lymphoma or CNS involvement of systemic lymphoma.
We intend to perform a retrospective chart review to identify a serum creatinine-based equation that gives the best estimate of CrCl as compared with an equation derived from a 24-hour urine collection. Study subjects will be identified using the Brigham and Women's Hospital and Dana-Farber Cancer Institute's Adult Pharmacy systems to identify patients who received high-dose methotrexate. Data will be collected starting with December 31, 2010 and proceeding chronologically backwards until the target enrollment of 40 patients is reached.
Study Type
OBSERVATIONAL
Enrollment
40
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
To identify a serum creatinine-based equation that gives the best estimate of CrCl as compared to a measured creatinine clearance formula.
Serum creatinine-based equations to be included in that analysis are: Cockcroft-Gault with the following weight descriptors; ideal body weight, actual body weight, and adjusted body weight; Modified MDRD; CKD-EPI.
Time frame: 1 year
To further compare each formula in a different subset of patients.
To further compare each formula in a different subset of patients: Age \< 65 years and \>/= 65 years; body mass index \< 25, 25-30, 30-35, and \> 35; serum creatinine \<1.5 mg/dL and \>/= 1.5 mg/dL.
Time frame: 1 year
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