The investigators will examine the balance between IVF success in terms of outcome parameters, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
100-150 mg of clomiphene citrate from day 2 till day 6 of the cycle and 150 mg of gonadotrophins as soon as 1 follicle is more than 14mm together with 1 fixed dose of GnRH antagonist until egg recovery
300-450 IU of FSH starting by day 2 of menstrual cycle together with a fixed dose of GnRH antagonist starting by day 6 till egg recovery, or same doses with GnRH agonist long protocol
3rd Department of Obstetrics & Gynecology, Assisted Reproduction Unit
Athens, Chaidari, Greece
number of oocytes (COCs)
Time frame: at oocyte recovery
Number/rate of participants whom the IVF cycle was cancelled
Time frame: After the 1st week of ovarian stimulation, no oocytes at OR
clinical pregnancy rate
Presence of fetal heart at transvaginal ultrasound at 6 weeks of gestation or 6 weeks after starting the intervention
Time frame: 6 weeks
live birth
Time frame: more than 20 weeks
miscarriage
Time frame: pregnancy loss before 20 weeks of gestation, after a positive pregnancy test
stimulation characteristics
total dose of gonadotropins administered,
Time frame: from start of stimulation until embryo transfer
cancellation rate
when premature ovulation was evident by the loss of follicle(s) prior to oocyte recovery, and in cases where there were no oocytes retrieved or no embryos produced for transfer and in failed fertilization
Time frame: from start of stimulation until ET
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