Preventive Treatment of Episodic and Chronic Migraine

Inclusion Criteria: * Migraine with or without aura or chronic migraine. * Subject age 18 to 70. * At least 2 migraine attacks per month. * Willing ang able to give written informed consent. * Willing and able to complete the entire course of the study and to comply with study instructions. * Willing to taper and discontinue their current preventive medications. Exclusion Criteria: * Subject is pregnant, lactating or planning a pregnancy in the next year. * Subject is female of child-bearing potential and not taking adequate forms of birth control. * Significant medical or psychiatric disease or abnormal laboratory data that would preclude entry into this study. * Previous failure of four or more adequate trials of preventive medication. * Currently on any form of antidepressant for depression and not able to discontinue. * Currently demonstrating medication overuse headache. * Currently has uncontrolled narrow angle glaucoma. * Currently taking monoamine oxidase inhibitors. * Subject has a history of seizures. * Participation in an investigational drug study within the last 30 days or 5 half-lives, whichever is longer.