A Study of a Single Dose of ASP3291 in Subjects With Ulcerative Colitis

Inclusion Criteria: * Subject has a previously documented diagnosis of ulcerative colitis (UC) with endoscopy and histology consistent with diagnosis * If female, the subject is at least 2 years postmenopausal or is surgically sterile per documentation provided by a third party medical professional or the subject agrees to use 2 highly effective methods of birth control during the study and is not pregnant or lactating * Subject is willing and able to comply with the study requirements * Subject has a body mass index (BMI) of \<32 kg/m2 * Subject has ulcerative colitis requiring treatment with 5-aminosalicylic acid (5-ASA) Exclusion Criteria: * Subject has undergone previous resective colonic surgery * Subject has previously diagnosed Crohn's Disease based on medical history * Subject has an extension of disease limited to ulcerative proctitis * Subject has active peptic ulcer disease based on medical history * Subject is currently being treated with any prescription medication except the following: A stable dose of 5-aminosalicylic acid (5-ASA) for at least 2 weeks, oral contraceptives or hormone replacement therapy (HRT) * Subject has a history of human immunodeficiency virus (HIV) * Subject has a history of severe allergic or anaphylactic reactions * Subject has a history of drug or alcohol abuse