Effect of Piroxicam on Ovulation

Inclusion Criteria: * Signed informed consent available before any study specific tests or procedures are performed * Healthy female subject * Age: 18 to 35 years (inclusive) at the first screening visit * Body mass index (BMI ): 18-30 kg/m² (inclusive) at the first screening visit * Confirmation of the subject's health insurance coverage prior to the first screening visit * Willingness to use non-hormonal methods of contraception during the study * Ability to understand and follow study-related instructions * Adequate venous access Exclusion Criteria: * Incompletely cured pre-existing diseases for which it can be assumed that the absorption, distribution, metabolism, elimination, and effects of the study drugs will not be normal * Hypersensitivity to the active substance or skin reactions (irrespective of severity) to piroxicam, non-steroidal anti-inflammatory drugs or other medicinal products in the past * History or presence of inflammatory diseases of the gastrointestinal tract, gastrointestinal bleeding, ulcers or perforation * Regular intake of medication other than hormonal contraceptives * Clinically relevant findings in the gynecological examination including transvaginal ultrasound (TVU) * Clinically relevant findings in the physical examination, especially signs of bleeding diathesis or heart failure * Time point "onset of LH surge" in the pre-treatment cycle not determinable * Time point "ovulation" in the pre-treatment cycle not determinable * Lacking suitability for frequent TVU examinations * History or presence of suffering from hay fever