Study of Inhaled Iloprost for the Treatment of Pulmonary Hypertension After Repair of Congenital Heart Disease

Inclusion Criteria: Before corrective procedure for CHD, two of bellow ten criteria should be met: * Decreased respiratory infection \& decreased exercise tolerance * Pulse SaO2 \< 93% in left-right shunt CHD case (in room air) * EKG: right ventricular hypertrophy, right atrial dilatation * Chest X-ray: enhanced vascular signs in trans-hilar, loss of blood vessel in bilateral lung fields, pulmonary arterial trunk dilatation, right ventricular enlargement * Cardiac echocardiography: fast tricuspid or pulmonary valve regurgitant velocity, ventricular and aortic level bidirectional shunt, or even right-to-left shunt * Underfilling of pulmonary capillary, 'pruning' of the peripheral blood vessels * Pp/Ps \> 0.75 * Qp/Qs \<1.5 * PVR \> 9WU/m2 * Rp/Rs \> 0.5 Exclusion Criteria: * a body weight of \< 2 kg, * prematurity (birth 36 weeks postconceptual age) * renal dysfunction (creatinine \>= 1.5 mg/dL 48 hours before surgery) * PLT \< 50,000\*109/L and obvious bleeding * LCOS or hypotension on arrival to the intensive care unit After corrective procedure for CHD: * deficient anatomy associated with remained intracardiac shunts and severe artrio-ventricular regurgitation * severe arrhythmia led to low cardiac output