Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects

Inclusion Criteria: * healthy * native or fluent German-speaking * BMI between 19 and 27 kg/m2 * able and willing to give written informed consent and comply with the requirements of the study protocol * willing to donate saliva sample for DNA-analysis * female: willing to perform a pregnancy test at the beginning of both test visits Exclusion Criteria: * acute or chronic psychiatric or somatic disorder * pathological ECG * known hypersensitivity to the IMP under investigation (losartan, diphenhydramine) * hypotension (RR \< 110/70 mmHg) * bradycardia (\< 50 bpm) * pregnancy, breast-feeding * long-term medication within last 3 months (oral contraceptives are disregarded) * smoking (\> 3 cigarettes per day) * concurrent participation in another study * participation in one of our previous studies using the same memory tests * inability to read and understand the participant's information