This study aims to determine the contribution of rotavirus infection as a cause of gastroenteritis requiring hospitalization in children younger than 5 years of age. Additionally, a secondary aim will be to determine the genotypes of rotavirus that cause these infections as prevalent in Lebanon.
This study will be performed at six large hospitals in Lebanon in the three largest cities Beirut, Tripoli, and Saida. The study will enroll children younger than 5 years of age who are admitted to the hospital because of gastroenteritis. Enrollment will continue for a period of two years at each hospital. Inclusion criteria are age \< 5 years, with gastroenteritis as the main reason for admission to the hospital or for a stay in the Emergency Department longer than 12 hours. Exclusion criteria include onset of symptoms beyond 12 hours of admission (health-care associated infection). For all enrolled subjects, data will be collected about severity of illness, outcome, and history of vaccination. Stool samples will be collected for genotyping of rotavirus.
Study Type
OBSERVATIONAL
Enrollment
1,555
American University of Beirut
Beirut, Lebanon
Makassed General Hospital
Beirut, Lebanon
Rafik Hariri University Hospital
Beirut, Lebanon
Nini Hospital
Tripoli, Lebanon
Estimating the Incidence of Rotavirus Gastroenteritis Associated Hospitalization in Children < 5 Years of Age
Incidence of rotavirus gastroenteritis associated hospitalization in children \< 5 years of age was 30.3% by PCR
Time frame: 2 years
Identifying the Most Prevalent RV Genotypes in the Target Population Included in the Surveillance Program
Time frame: 2 years
Estimating the Proportion of Diarrheal Hospitalization Due to RV in Children < 5 Years of Age.
Time frame: 2 years
Determining the Age and Seasonal Distribution of RV Associated Hospitalizations in Children < 5 Years of Age
Time frame: 2 years
Determining Seasonal Changes and Year-to-year Changes With Respect to Predominant RV Genotypes
Time frame: 2 years
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