Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)

N/ACompletedNCT01322074

Hvidovre University Hospital120 enrolled

Overview

In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).

The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated. Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation). We pole blood-samples collected prospectively (from two data set)

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Other Acute Postoperative Pain Systemic Inflammatory Response Syndrome

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elective unilateral primary total knee arthroplasty * Able to speak and understand danish * Able to give informed consent Exclusion Criteria: * Alcohol or medical abuse * Allergies to local anesthetics or methylprednisolone * Age \< 18 years old * Daily use of strong opioids or glucocorticoids * Pregnancy or breastfeeding (fertile women) * Bilateral / revision arthroplasty * Dementia or other cognitive dysfunction * Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception

Locations (1)

Dep. of Anesthsiology, Hvidovre University Hospital

Copenhagen, Hvidovre, Denmark

Outcomes

Primary Outcomes

Systemic inflammation vs. pain

The correlation between pain and systemic inflammatory markers (CRP and IL6)

Time frame: 1 week

Data from ClinicalTrials.gov

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