National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

Eligible subjects must have one of the conditions listed below and be enrolled in-person at one of the participating clinical centers.Contact the study coordinator at the location nearest you for more information about participation. * Marfan syndrome * Turner syndrome * Ehlers-Danlos syndrome * Loeys-Dietz syndrome * FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 genetic mutation * Bicuspid aortic valve without known family history * Bicuspid aortic valve with family history * Bicuspid aortic valve with coarctation * Familial Thoracic Aortic Aneurysm and DissectionsYes * Shprintzen-Goldberg syndrome * Other aneurysms and dissections of the thoracic aorta not due to trauma, \<50yo * Other congenital heart disease (e.g., Tetralogy of Fallot, coarctation) Exclusion Criteria: * Inability of the patient, parent or guardian to give consent. * Unwillingness to provide a blood or buccal specimen.