The purpose of this study is to determine whether helmet is effective as device for noninvasive positive pressure ventilation in the weaning from mechanical ventilation.
The clinical efficacy of noninvasive positive pressure ventilation (NPPV) has been demonstrated. Interest has emerged in using NPPV to facilitate earlier removal of an endotracheal tube and decrease complications associated with prolonged intubation. Studies assessing NPPV in weaning are not enough and generally are performed with face masks as device for NPPV. This study assesses the efficacy of helmet as device for NPPV during weaning from mechanical ventilation in an ICU and compares this procedure with invasive mechanical complication (IMV) by analyzing respiratory parameters, clinical course and complications.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
250
Weaning from mechanical ventilation with noninvasive positive pressure ventilation delivered by means of the helmet
Weaning from mechanical ventilation with invasive mechanical ventilation delivered by means of the endotracheal tube
University Medical Hospital
Padua, Italy
Weaning using noninvasive positive pressure ventilation by means of helmet in patients with acute respiratory failure
Main end-point defined as the weaning success/failure rate
Time frame: 30 days
Weaning using noninvasive positive pressure ventilation by means of helmet in patients with acute respiratory failure
* Intubation duration * Total duration of mechanical ventilation (endotracheal and non invasive) * Weaning process duration * Stress response evaluation * Daily duration of ventilatory support * ICU lentgh of stay * Hospital lentgh of stay
Time frame: 180 days
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