Physical Activity in Overweight Girls: Implications for Reversing Risk Factors for Type 2 Diabetes

University of Pittsburgh44 enrolled

Overview

In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, ectopic fat in the liver and skeletal muscle, and risk of type 2 diabetes in overweight girls.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Abdominal Obesity Physical Activity

Interventions

ControlOTHER

Standard care control (no exercise)

Resistance ExerciseOTHER

Supervised resistance exercise using stack weight equipments.

Aerobic exerciseOTHER

Supervised aerobic exercise using treadmills, bikes, and ellipticals

Eligibility

Sex: FEMALEMin age: 12 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy overweight (BMI \>-95th) youth between 12 and 18 years of age * Waist circumference \>-75th percentile * Sedentary (no structured exercise \>2 times/week for past 6 months) * Non-smokers, non-diabetic, no medical conditions * Weight stable for past 3 months Exclusion Criteria: * Smokers * Diabetes * Psychiatric disorders * Syndromic obesity * Pregnancy * Taking medications known to affect study outcomes

Locations (1)

Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine

Pittsburgh, Pennsylvania, United States

Outcomes

Primary Outcomes

Abdominal obesity, visceral fat

Time frame: 3 month

Secondary Outcomes

insulin sensitivity by a 3-hour hyperinsulinemic-euglycemic clamp, oral glucose tolerance test, liver fat and intramyocellular lipid by 1H-magnetic resonance spectroscopy.

Time frame: 3 month

Data from ClinicalTrials.gov

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