Preopioid Versus Nonopioid in Total Knee Arthroplasty (TKA)

Hvidovre University Hospital140 enrolled

Overview

Observational study evaluating pain response after total knee arthroplasty (TKA) in patients taking strong, weak or no opioids preoperatively.

Study Type

OBSERVATIONAL

Enrollment

140

Conditions

Postoperative Pain

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients operated with elective, primary, unilateral total knee arthroplasty (TKA) (taking strong or weak opioid daily for minimum 4 weeks or opioid naive patients) Exclusion Criteria: * Bilateral / revision arthroplasty * Disease affection central or peripheral nerve function * Alcohol and medical abuse * Daily use of glucocorticoids * Malignancy * BMI \> 40 * Dementia or other cognitive dysfunction * Treatment of anxiety or depression

Locations (4)

Dep. of ortopedic surgery, Gentofte Hospital

Hellerup, Hellerup, Denmark

Dep. of ortopedic surgery, Regionshospitalet Holstebro

Holstebro, Holstebro, Denmark

Dep. of Anesthesiology, Hvidovre University Hospital

Copenhagen, Hvidovre, Denmark

Dep. of ortopedic surgery, Vejle Sygehus

Vejle, Vejle, Denmark

Outcomes

Primary Outcomes

Pain

Pain during ambulation and at rest

Time frame: 24 hours

Secondary Outcomes

Pain

Pain during ambulation and at rest

Time frame: 7 days

Opioid consumption

Time frame: 7 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.