Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling

China Medical University Hospital3 enrolled

Overview

The first year purpose: The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.

Our previous work is investigating the viral (Adv-BMP-2) administration for the development of a model to generate bones for possible use in clinical settings; the non-viral and viral administrations will be compared for best osteogenesis effects. The first year purpose: The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Primary Disease

Eligibility

Sex: ALLMin age: 10 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age above 10 years old * The patients require surgery ner iliac or abdomen areas Exclusion Criteria: * age below 10 years old

Locations (1)

China Medical Universty Hospital

Taichung, Taiwan

Outcomes

Primary Outcomes

Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling/Hydroxyapatite Nanoparticles--Comparisons between Non-viral and Viral administration in Tissue Engineered Bone Regeneration

August 2011-July 2013

Time frame: 2 years

Data from ClinicalTrials.gov

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