Lubiprostone as an adjunct to the standard bowel preparation regime the quality of bowel preparation can be improved for a good colonoscopic examination without missing lesions and complications.
Objectives: 1. Primary: * Same day Low volume PEG with placebo (Arm 1) versus same day low volume PEG with Lubiprostone (Arm 2) * Waiting time for colonoscopic procedure and quality of bowel preparation 2. Secondary: * Quality of bowel preparation without Dietary restriction (Modified bowel preparation regime without Fiber diet restrictions)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
442
Lubiprostone is a chloride channel activator approved by the Food and Drug Administration for the treatment of chronic constipation. A randomized, double-blind, parallel-group, placebo-controlled study evaluating the effect of lubiprostone on gastric function showed slowed gastric emptying and increased small bowel and colonic transit time. Peak plasma concentration was shown to be around 1.14 hours, with a majority of the drug excreted in the urine within 48 hours.
Quality of bowel preparation in Same day Low volume PEG with placebo versus same day low volume PEG with Lubiprostone
Quality of bowel preparation is based on Boston Bowel Preparation Score (BBPS)
Time frame: 2 months
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