The Topical Niacin Skin Flush Test in First Episode Psychosis

Inclusion Criteria: * caucasian * within twelve months of initial DSM IV TR diagnosis of schizophreniform psychosis, schizophrenia, schizoaffective disorder or psychotic disorder NOS * outpatient Exclusion Criteria: * known allergy to study compound (methyl nicotinate, vitamin B3, niacin) * skin conditions (e.g., dermatitis, psoriasis, eczema) * diagnosis or treatment for medical conditions that may affect normal vascular tone (e.g., diabetes, vasculitis, chronic hypertension, etc.) * Use of anti-inflammatory, antibiotic, or antihistamine medications within one month prior to study entry * Use of supplements like Omega 3 fatty acids within 3 months prior to study entry * Use of vitamin or nutritional supplement containing a dose of niacin/nicotinic acid above 50 mg/day at study entry