A Placebo-controlled Four Way Crossover Study to Asses the Effect of a Single Oral Dose of NKTR-118 on QTc Interval in Healthy Male Subjects

Inclusion Criteria: * Healthy male subjects aged 18 to 50 years (inclusive) with suitable veins for cannulation or repeated venipuncture. * Body mass index (BMI) between 18 and 30 kg/m2 (inclusive) and weight at least 50 kg but no more than 100 kg. Exclusion Criteria: * Clinically significant medical history including severe allergies or a history of mental disorders or any cardiac history, history or presence of gastrointestinal, hepatic, or renal disease. * Abnormal heart rhythm including any abnormal arrhythmias, marked sinus arrhythmias, or junctional rhythms. * Known or suspected history of drug abuse, current smokers or those who have smoked and/or used nicotine products within 3 months prior to enrollment. * Excessive intake of caffeine-containing products