To evaluate the efficacy and safety of tacrolimus capsules in patients with myasthenia gravis who are inadequately treated by glucocorticoid.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
83
oral
oral
Unnamed facility
Beijing, China
Unnamed facility
Guangdong, China
Unnamed facility
Jiangsu, China
Unnamed facility
Jilin City, China
Change from baseline in quantitative myasthenia gravis (QMG) score for disease severity
Time frame: Baseline and at 24 weeks
Change from baseline in QMG score for disease severity
Time frame: Baseline and at 4 weeks
Change from baseline in QMG score for disease severity
Time frame: Baseline and at 8 weeks
Change from baseline in QMG score for disease severity
Time frame: Baseline and at 12 weeks
Change from baseline in QMG score for disease severity
Time frame: Baseline and at 16 weeks
Change from baseline in QMG score for disease severity
Time frame: Baseline and at 20 weeks
Changes in Osserman classification
Time frame: Baseline and at 4 weeks, 8 weeks, 12 weeks, 16 weeks, 20 weeks and 24 weeks
Changes in myasthenia gravis activity of daily living scale
Time frame: Baseline and at 4 weeks, 8 weeks, 12 weeks, 16 weeks, 20 weeks and 24 weeks
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Unnamed facility
Shandong, China
Unnamed facility
Shanghai, China
Unnamed facility
Sichuan, China
Unnamed facility
Wuhan, China
Unnamed facility
Zhejiang, China