The objective of the study is to provide proof that a MRI based preoperative radiochemotherapy in patients with locally advanced rectal carcinoma allows limiting RCT to high risk patients without increase of locoregional recurrence rate and decrease of overall survival provided there is a high quality of mesorectal excision.
The criteria for application of RCT is the distance of the tumor from mesorectal fascia in preoperative MRI of the pelvis. In case of a T 4 tumor or a tumor with a distance of 1mm of less form mesorectal fascia long-course radiochemotherapy is applied followed by surgery, in all other cases primary surgery is done.
Study Type
OBSERVATIONAL
Enrollment
1,051
long course 5-FU based radiochemotherapy before total mesorectal excision
University Medicine Center Department of General and Abdomial Surgery
Mainz, Germany
Locoregional recurrence rate
Time frame: Five year
Rate of involvement of circumferential resection margin (pCRM positive of resected specimens
pCRM positive means a distance of the tumor from circumferential resection margin 1mm or less.
Time frame: postoperative
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