The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery

Yonsei University45 enrolled

Overview

This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Prostate Cancer

Interventions

Epidural anesthesiaPROCEDURE

0.5% ropivacaine infusion via epidural catheter at 5ml/hr during general anesthesia

Eligibility

Sex: MALEMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy Exclusion Criteria: * Patient refusal * Patients on diuretics * Patients with renal failure (eGFR \< 60 ml/min/1.73 m2)

Locations (1)

Severance Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

blood pressure with heart rate variability

Time frame: 10 minutes after anesthesia induction

Data from ClinicalTrials.gov

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