The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
40
PEEP is set according to the following protocols, respectively, in a randomized order: ARDSnet table, Open Lung strategy, guided by EIT
University Hospital
Bonn, Germany
RECRUITINGhomogeneity of regional ventilation delay
influence of different PEEP titration strategies on homogeneity of regional ventilation delay measured by electrical impedance tomography
Time frame: up to eight hours
pulmonary gas exchange, lung mechanics and ventilation/perfusion matching
influence of different PEEP titration strategies on pulmonary gas exchange, lung mechanics and ventilation/perfusion matching
Time frame: up to eight hours
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