The study will test the hypothesis that supplementing the diet of subjects with Metabolic Syndrome with 2000 IU vitamin D and 1.8 g omega-3 fatty acids (EPA + DHA) per day, will facilitate weight loss, improve body composition and reduce metabolic and biochemical risk factors associated with type II diabetes and cardiovascular disease. Adult men and women who meet the International Diabetes Federation criteria for Metabolic Syndrome will be enrolled and embark on a 16 week diet and exercise intervention using a low glycemic index diet with or without the supplementary vitamin D and omega-3. Subjects will be counseled weekly and blood collected at weeks 0 and 16.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
a low glycemic diet, calorie restricted with exercise sessions 3 times per week
2000 IU vitamin D3 plus 1.8 g EPA + DHA per day for 16 weeks.
University of Guelph
Guelph, Ontario, Canada
body weight
body weight will be measured to nearest 0.5 kg weekly
Time frame: up to 16 weeks
Blood pressure
systolic and diastolic blood pressure will be measured in duplicate, weekly
Time frame: up to 16 weeks
Blood lipids
blood lipids will be measured at baseline and after study completion.
Time frame: up to 16 weeks
Glucose homeostasis
fasting blood glucose, insulin, HbA1c, CRP, cytokines and inflammatory markers will be measured at weeks 0 and 16 of the intervention.
Time frame: up to 16 weeks
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