The hypothesis of this study is that PGF2alpha does not induce headache or dilatation of brain vessels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
12
intravenous injection
intravenous injection
Danish Headache Center
Glostrup Municipality, Denmark
Headache score on a 10-point verbal rating scale (VRS) 0 indicated no headache; 1 indicated a different sensation, pounding or throbbing, but not necessarily painful; 5 indicated moderate headache and 10 indicated worst imaginable headache
incidence of headache
Time frame: 24 h.
Blood flow velocity in the middle cerebral artery (VMCA) measured by a Transcranial Doppler (TCD) ultrasonography (2MHz)
changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: in-hospital 2 h.
diameter of superficial temporal artery and radial artery measured by a high resolution ultrasound scanner, C-scan
changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: in-hospital 2 h.
mean arterial blood pressure (MAP), heart rate (HR), end-tidal partial pressure of pCO2 (PetCO2), transcutaneous arterial oxygen saturation (SAT) measured by ProPac Encore®
changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: in-hospital 2 h.
electrocardiography (ECG)
changes from base line recorded every 10th min. until time 90 min on day 1 and day 2. The infusion takes 25 min from time 0.
Time frame: in-hospital 2 h.
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