A Study to Compare Genetic Variations of IGF-I and IGF-II

Avera McKennan Hospital & University Health Center50 enrolled

Overview

The purpose of this study is to determine if insulin-like growth factors (IGF) play a role in the development of dementia, specifically Alzheimer's disease (AD). The study will compare results from genetic testing between patients with AD and two other groups: younger biological family members of the AD patients and individuals without AD matched by age to the AD patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dementia

Eligibility

Sex: ALLMin age: 50 YearsMax age: 81 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women between the ages of 50 and 81 years old who have a diagnosis of dementia * Men and women who are at least 18 years old and are biologically related to the study subject with dementia * Control subjects must not have a diagnosis of dementia and must be matched in age to the study subjects with dementia Exclusion Criteria: * Biological family members of the dementia patient who are either younger than 17 years of age or older than the patient with dementia * Biological family members with a diagnosis of dementia * Age-matched control subjects with a diagnosis of dementia

Locations (1)

Avera Research Institute

Sioux Falls, South Dakota, United States

Outcomes

Primary Outcomes

Genetic polymorphisms of insulin-like growth factors

This study consists of a single clinic visit. After subject has completed the informed consent process and meets eligibility criteria, a blood sample and a saliva sample will be collected. Genetic results from this one-time specimen collection will be evaluated and compared with results from participants in the other two study groups. Outcomes will be measured comparatively.

Time frame: Single clinic visit (day 1)

Secondary Outcomes

Genetic testing of Apolipoprotein (APO) E4

Time frame: Single clinic visit (day 1)

Data from ClinicalTrials.gov

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