If the risk of dementia occurrence after stroke is well known, few data exist about the factors influencing positively or negatively the developement of cognitive disorders or dementia. The aim of the study is so to determine prospectively the clinical, biological, lesional and pharmacological factors associated with post-stroke dementia by the long-term follow-up of a stroke patient cohort.
The STROKDEM study is based on the 5-year prospective follow-up of a population of 1100 stroke patients without dementia. At inclusion in the cohort, main antecedents and risk factors, previous treatment and lifestyle, initial severity and etiology are recorded. Biological samples (for standard ans specialized analyses) and MRI are performed at 72h after stroke occurrence. Thereafter, patients are regularly (6 months, 12 months, 36 months, 60 months) examined for clinical and cognitive assessment with biological samples and Magnetic Resonance Imaging. Patients with dementia will be compared to patients without stroke to identify, by logistic regression analysis and Cox model, the factors associated with dementia occurrence.
Study Type
OBSERVATIONAL
Enrollment
229
Amiens University Hospital
Amiens, France
Caen University Hospital
Caen, France
Lille University Hospital
Lille, France
Rouen University Hospital
Rouen, France
dementia occurrence
This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient and his/her family.
Time frame: 60 months
dementia occurrence and cognitive impairment
This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient and his/her family. Impairment of some tests of cognitive battery without significant impairment in activities of daily living
Time frame: 6 months
dementia occurrence and cognitive impairment
This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient ans his/her family. Impairment of some tests of cognitive battery without significant impairment in activities of daily living
Time frame: 12 months
dementia occurence and cognitive impairment
This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient ans his/her family. Impairment of some tests of cognitive battery without significant impairment in activities of daily living
Time frame: 36 months
cognitive impairment
Impairment of some tests of cognitive battery without significant impairment in activities of daily living
Time frame: 36 months
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