Drug-drug Interaction Study (CKD-501, Ketoconazole)

Inclusion Criteria: * Between 20 aged and 45 years old in healthy males * 18.5 ≤ IBW \< 25 * Agreement with written informed consent Exclusion Criteria: * Hypersensitivity reactions to drugs or clinically significant hypersensitivity reactions in the history of party * Medication with drug-mediated induction/inhibition metabolic enzyme such as Midazolam within 1 month or with may affect the clinical trial * Subject has taken abnormal meals which affects the ADME of drug * Subject has a history(such as gastric or duodenal ulcer, gastrointestinal surgical histories except for an appendectomy) affects the ADME of drug * Substance abuse, or a history of drug abuse showed a positive for the party * Continued to be taking caffeine (caffeine \> 5 cup/day), drinking (alcohol \> 210 g/week) or cannot stop drinking or severe heavy smoker(cigarette \> 10 cigarettes per day)during clinical trials * Previously participated in other trial within 60 days * Previously donate whole blood within 60 days or component blood within 30 days * Inadequate subject by medical examination(medical history, physical examination, ECG, laboratory test) within 28 days of starting administration of investigational drug * SBP \>140 mmHg, SBP \< 90 mmHg or DBP \> 90 mmHg, DBP \< 50 mmHg or Pulse \> 100 per/min, Pulse \< 50 per/min * 12-lead ECG, QTc \> 450 msec * An impossible one who participates in clinical trial by investigator's decision including laboratory test result