Effect of Diet Orange Soda on Urinary Lithogenicity

VA New York Harbor Healthcare System12 enrolled

Overview

Beverages containing citrate may be useful in increasing urine citrate content and urine pH. Such changes in urine chemistry could help prevent kidney stones. Diet orange soda has more citrate than other similar beverages. The investigators are interested in whether diet soda will improve urine chemistry in the appropriate manner.

The effect of orange soda compared with water in changing 24 hour urine citrate excretion in mg/day will be determined.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Kidney Stones Nephrolithiasis Urolithiasis

Interventions

Orange sodaDIETARY_SUPPLEMENT

32 ounces per day

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-65 years old * able to sign consent * ability to reliably urinate into a vessel and measure urine volume Exclusion Criteria: * prior history of nephrolithiasis * a known history of metabolic bone disease * hyperthyroidism * hyperparathyroidism or chronic kidney disease * current use of diuretics * current use of potassium citrate or other oral alkali supplementation and * use of calcium supplementation that could not be stopped

Locations (1)

New York Harbor VA Medical Center

New York, New York, United States

Outcomes

Primary Outcomes

Change in urine citrate content

Citrate is measured in 24h urine sample and expressed as mg/day

Time frame: 1 week

Secondary Outcomes

Change in urine pH

urine pH is measured in a 24h urine sample and has no units

Time frame: One week

Data from ClinicalTrials.gov

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