Study of Pazopanib in the Treatment of Surgically Unresectable or Metastatic Chondrosarcoma

Inclusion Criteria: * Written informed consent. * Age \> or = to 18 years. * Histologically confirmed diagnosis of conventional chondrosarcoma of any grade. * Surgically unresectable or metastatic disease. * Any number of prior treatment regimens, including treatment naive subjects. Prior treatment with tyrosine kinase inhibitors is permitted. * Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2. * Measurable or evaluable (non-measurable) disease per RECIST guidelines version 1.1. * Adequate organ system function determined within 14 days prior to first dose of study treatment. * Left ventricular ejection fraction \> 50% or the institutional LLN within 28 days prior to the first dose of study treatment. * Females must either be of non-child bearing potential or have a negative serum pregnancy test within 7 days prior to the first dose of study treatment. Exclusion Criteria: * Prior treatment with pazopanib. * Mesenchymal, dedifferentiated, and extraskeletal myxoid chondrosarcoma subtypes. * Prior malignancy (Note: subjects who have had another malignancy and have been disease-free for 3 years, or subjects with a history of completely resected non-melanomatous skin carcinoma or successfully treated in situ carcinoma are eligible). * History or clinical evidence of central nervous system (CNS) metastases or leptomeningeal carcinomatosis, unless previously treated, asymptomatic, and off steroids and anti-seizure medication for 6 months prior to first dose of study drug. * Clinically significant gastrointestinal (GI) abnormalities that may increase the risk for GI bleeding. * Clinically significant GI abnormalities that may affect absorption of investigational product. * Presence of uncontrolled infection. * Corrected QT interval \> 480 msecs using Bazett's formula. * History of certain cardiovascular conditions within the past 6 months. * Poorly controlled hypertension \[defined as systolic blood pressure of \> or = 140 mmHg or diastolic blood pressure of \> or = 90 mmHg\]. * History of cerebrovascular accident including transient ischemic attack, pulmonary embolism, or untreated deep venous thrombosis within the past 6 months. * Prior major surgery or trauma within 28 days prior to the first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer. * Evidence of active bleeding or bleeding diathesis. * Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage. * Hemoptysis in excess of 2.5 mL within 8 weeks of first dose of study drug. * Any serious and/or unstable pre-existing medical, psychiatric, or other condition that could interfere with subject's safety, provision of informed consent, or compliance to study procedures. * Unable or unwilling to discontinue use of prohibited medications for at least 14 days or five half-lives of a drug (whichever is longer) prior to the first dose of study drug and for the duration of study treatment. * Radiation therapy, surgery (except major surgery), tumor embolization, chemotherapy, immunotherapy, biologic therapy, investigational therapy, or hormonal therapy within 14 days or five half-lives of a drug (whichever is longer) prior to the first dose of study drug. * Any ongoing toxicity from prior anti-cancer therapy that is \> Grade 1 and/or that is progressing in severity, except alopecia. * Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib or excipients that contraindicates participation.